2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-118019
    Scandenolide 23758-16-9 98%
    Scandenolide is a sesquiterpene lactone that can be found in Philippines medicinal plant Mikania cordata. Scandenolide inhibits leukotriene and platelet activating factor synthesis in leukocytes.
    Scandenolide
  • HY-118033
    SQ 30774 121995-36-6 98%
    SQ 30774 is a renin (renin) inhibitor. SQ 30774 has potent in vitro inhibitory effects in primates but not in rats, pigs, or dogs. And imidazolinol renin inhibitors also inhibit PRA and reduce arterial blood pressure in vivo.
    SQ 30774
  • HY-118039
    Abanoquil methylsulfate 118931-00-3 98%
    Abanoquil methylsulfate (UK-52046 methylsulfate) is an alpha-1 family adrenergic receptor antagonist. Abanoquil methylsulfate can be used in research on cardiovascular diseases such as arrhythmias and erectile dysfunction.
    Abanoquil methylsulfate
  • HY-118044
    I-SAP 133538-58-6 98%
    I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC).
    I-SAP
  • HY-118046
    GSK2163632A 1123163-20-1 98%
    GSK2163632A is a selective G protein-coupled receptor kinase (GRK) inhibitor that can be used as a probe for studying heart failure and Parkinson's disease. GSK2163632A potently inhibits GRK1 and GRK5, and also inhibits Rho-associated coiled-coil kinase (ROCK) and insulin-like growth factor receptor IGF-1R. GSK2163632A binds to GRK2 in a manner similar to Paroxetine (HY-122272).
    GSK2163632A
  • HY-118050
    L589420-0-2 1431-30-7 98%
    L589420-0-2 (L-420) is a sodium pump inhibitor with inhibitory activity in human erythrocytes. L589420-0-2 can regulate the concentration of intracellular sodium ions, thereby affecting the electrophysiological properties of cells. L589420-0-2 may also play an important role in the inhibition of cardiovascular diseases.
    L589420-0-2
  • HY-118084
    LS-104 368836-72-0 98%
    LS-104 (Tyrene CR-4) is a non-ATP-competitive kinase inhibitor against JAK2, Bcr-Abl and FLT3. LS-104 potently induces apoptosis in JAK2V617F-positive cells and inhibits JAK2 autophosphorylation and downstream signal transduction. LS-104 also inhibits proliferation and induces potent cytotoxic effects in FLT3 expressing leukemic cells. LS-104 is a hydroxystyryl-acrylonitrile compound, which is promising for research of myeloproliferative disorders and refractory/relapsed hematologic malignancies.
    LS-104
  • HY-118094
    8-iso Prostaglandin E1 21003-46-3 98%
    8-iso Prostaglandin E1 (Ovinonic acid; 8-iso-PGE1) is a spasmodic agent in canine pulmonary veins and can also cause vasodilation.
    8-iso Prostaglandin E1
  • HY-118148
    UK-66914 113049-11-9 98%
    UK-66914, is a class III antiarrhythmic agent that specifically acts on the delayed rectifier potassium current (I_K). UK-66914 is designed to prolong action potential duration (APD) and increase cardiac refractory period, thereby potentially terminating the reentry mechanism in arrhythmias without affecting the serious side effects of antiarrhythmic drugs associated with other ion channels such as Na+ and Ca2+ currents.
    UK-66914
  • HY-118160
    PPM-18 65240-86-0 99.17%
    PPM-18 (NSC 73233) is a Vitamin K (HY-B2172) analog. PPM-18 prevents LPS-induced IκBα degradation, thereby inhibiting NF-κB activation and nuclear translocation of NF-κB. PPM-18 inhibits LPS-induced nitrite production and iNOS expression. PPM-18 inhibits HDAC6. PPM-18 induces ROS accumulation, activates AMPK, inhibits the mTORC1 and PI3K/AKT pathways, initiates Autophagy, and induces Apoptosis. PPM-18 suppresses seizures in zebrafish and mouse epilepsy models. PPM-18 prevents LPS-induced lethal toxicity and delayed hypotension. PPM-18 exhibits anticancer activity against leukemia and bladder cancer. PPM-18 can be used in research related to septic shock, bladder cancer and atherosclerosis.
    PPM-18
  • HY-118172
    PD-307243 313533-41-4 98%
    PD-307243 is a hERG channel activator. PD-307243 can be used for research of arrhythmias.
    PD-307243
  • HY-118202
    (-)-Gallopamil 36622-40-9 98%
    (-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of ICa decay (as well as the voltage-dependent decay of Ba2+ currents). (-)-Gallopamil is promising for research of antiarrhythmics.
    (-)-Gallopamil
  • HY-118220
    EP 171 122089-44-5 98%
    EP 171 is a TP receptor agonist and human platelet activator. EP 171 can induce constriction of guinea pig trachea, and the constriction can be inhibited by the TP receptor antagonist EP 092. EP 171 binds to TP receptors on intact human platelets with an IC50 of 2.9 nM.
    EP 171
  • HY-118229
    CGS 24012 120442-40-2 98%
    CGS 24012 (DPMA) is a selective adenosine A2 agonist. CGS 24012 produces significant increases in cardiac output. CGS 24012 reduces renal vascular resistance to the greatest extent and produces a concomitant significant increase in renal blood flow. CGS 24012 can be used in the research of hypertension.
    CGS 24012
  • HY-118294
    15-OH Tafluprost 130209-78-8 98%
    15-OH Tafluprost, a prostaglandin F2a (PGF2a) analog, relieves endothelin-1 (ET-1)-induced optic nerve head (ONH) blood flow impairment and ET-1-induced contraction of isolated ciliary artery segments.
    15-OH Tafluprost
  • HY-118339
    PF-4479745 1065110-43-1 98%
    PF-4479745 is a potent and selective 5-HT2C receptor agonist (EC50: 10 nM, ki: 15 nM). PF-4479745 can be used in the research of cardiovascular disease like hypertension.
    PF-4479745
  • HY-118390
    Jingsongling 25332-05-2 98%
    Jingsongling is a Xylazine analog and anesthetic agent. Jingsongling causes bradycardia and hypertension by mediating α2-adrenoceptors. Jingsongling inhibits canine gastric motility through mediation of α1 and α2 adrenergic receptors.
    Jingsongling
  • HY-118410
    L-738167 163212-43-9 98%
    L-738167 is an orally active fibrogen receptor antagonist that prevents the binding of fibrinogen to GP IIb/IIIa. L-738167 can be utilized in thrombus research.
    L-738167
  • HY-118488
    L 640035 77167-93-2 98%
    L 640035 is athromboxaneantagonist.
    L 640035
  • HY-118605
    Aminometradine 642-44-4 98%
    Aminometradine is an orally active diuretic. Aminometradine increases urine volume and the excretion of sodium and chloride. Aminometradine can be used in studies of congestive heart failure.
    Aminometradine
Cat. No. Product Name / Synonyms Application Reactivity